Detalhe da pesquisa
1.
Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions.
Neurobiol Dis
; 191: 106411, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38228253
2.
Deficits in basal and evoked striatal dopamine release following alpha-synuclein preformed fibril injection: An in vivo microdialysis study.
Eur J Neurosci
; 59(7): 1585-1603, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38356120
3.
Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition.
J Neuroinflammation
; 21(1): 108, 2024 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38664840
4.
Striatal Afferent BDNF Is Disrupted by Synucleinopathy and Partially Restored by STN DBS.
J Neurosci
; 41(9): 2039-2052, 2021 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33472823
5.
Leveraging the preformed fibril model to distinguish between alpha-synuclein inclusion- and nigrostriatal degeneration-associated immunogenicity.
Neurobiol Dis
; 171: 105804, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35764290
6.
Dopaminergic Positron Emission Tomography Imaging in the Alpha-Synuclein Preformed Fibril Model Reveals Similarities to Early Parkinson's Disease.
Mov Disord
; 37(8): 1739-1748, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35524682
7.
Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils.
Neurobiol Dis
; 130: 104525, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31276792
8.
Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils.
NPJ Parkinsons Dis
; 10(1): 7, 2024 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38172128
9.
Microglial depletion does not impact alpha-synuclein aggregation or nigrostriatal degeneration in the rat preformed fibril model.
Res Sq
; 2023 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37205534
10.
Developmental exposure to the Parkinson's disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice.
Toxicol Sci
; 196(1): 99-111, 2023 10 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37607008
11.
Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein.
NPJ Parkinsons Dis
; 8(1): 61, 2022 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35610264
12.
Mitochondrial and calcium perturbations in rat CNS neurons induce calpain-cleavage of Parkin: Phosphatase inhibition stabilizes pSer65Parkin reducing its calpain-cleavage.
Biochim Biophys Acta Mol Basis Dis
; 1865(6): 1436-1450, 2019 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30796971
13.
Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson's Disease.
Front Neurosci
; 12: 621, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30233303